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Treating Depression with Magic Mushrooms - The active ingredient in psychedelic mushrooms is called psilocybin. It can treat depression when other drugs have failed. Here is how it works: Psilocybin helps "loosen" the deeply-rooted patterns of thinking and behavior behind many of these mental disorders. It "relaxes" the parts of the brain that controls these behaviors, thus allowing old patterns to change or fade for good. Patients who have received psilocybin have described coming down from the high with "new insights" and changed perspectives on their sadness.