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Completely revised and expanded, this new edition now includes a section on medical systems biology and comes in a large format with a vastly improved layout, professional artwork throughout, and student-friendly reading lists. The experienced author team has worked closely to ensure a homogenous style and comprehensive coverage without overlaps. The text retains its easily accessible style and includes numerous work examples and study questions in each chapter. The greatly improved companion website features a complete set of figures, a summary for exam preparations and modeling software for study purposes. Now that systems biology is becoming an integral part of the life science curriculum, this textbook is geared towards biologists, engineers and computer scientists.