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"Polarization-Based Optical Imaging for Clinical Diagnostics" presents a comprehensive methodology for optical mapping of biological tissues and fluids using 3D Jones-Mueller digital holography. It covers physical principles, experimental systems, and data analysis algorithms, offering a unified theory for polarization-based diagnostics. The book includes applications in oncology, cardiology, gynecology, and forensic medicine, demonstrating its clinical relevance. What sets this book apart is its integration of statistical, fractal, and wavelet analyses with advanced imaging techniques, enabling precise differentiation of pathological states. It also features software tools and image libraries, making it both a reference and a practical guide for modern biomedical diagnostics.