Integrative Omics and Systems Pharmacology for Covid-19 (el. knyga) (skaityta knyga) | knygos.lt

Aprašymas

In 2019, the emerging RNA virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), gained the ability to infect human beings, then turned into human-to-human transmission, and eventually led to a pandemic of coronavirus disease 2019 (COVID-19), causing serious damage not only to global public health but also economic activities for years. Now, fast-mutating SARS-CoV-2 continues to produce new variants that threaten the world. As such, there is still a high demand for the development of effective treatments for combating new variants of SARS-CoV-2 infection and mitigating diverse post-COVID symptoms, including those who are long-COVID patients.

This book introduces cutting-edge ways for drug discovery and pharmacological approaches to develop treatments and medications for COVID-19, based on modern technologies that highlight the applications of integrated multiple omics and advanced bioinformatics tools. A comprehensive overview of COVID-19 is provided, focusing on the impact of new variants and the emerging trend of vaccine development. This book also presents efficient modern strategies for developing drugs and immunotherapeutics using in silico and integrated pharmacology, through uncovering chief host/viral protein targets such as angiotensinogen-converting enzyme 2 (ACE-2), toll-like receptors (TLRs), transmembrane serine protease 2 (TMPRSS2), papain-like protease (PLpro), main protease (Mpro), 3-chymotrypsin-like protease (3CLpro), and RNA-dependent RNA polymerase (RdRp), etc., and cellular processes involving several important infectious and inflammatory pathways. Theoretically, by inhibiting and controlling the activity of these crucial protein targets, anti-virus agents might suppress COVID-19 infection, mitigate COVID-19 symptoms, and prevent the development of long-COVID.

This book presents a powerful way to discover drug candidates performed by systems/network pharmacology. It systematically lists a range of promising bioactive compounds derived from traditional herbal medicines and natural products. The book explains the expanding strategy to integrate a series of approaches including genomics, metagenomics, transcriptomics, proteomics, metabolomics, epigenomics, and bioinformatics to organize a system of multiple omics. International and reliable multi-omics databases, bioinformatics tools, and software are comprehensively summarized and thus can be easily accessed by researchers.

Artificial intelligence (AI) as a revolutionary tool in the fields of drug discovery, vaccine development, and computational medicine for COVID-19 is also addressed. The coordination and integration of AI tools within the system of multiple omics, and the limitations and future directions of AI-assisted strategies for COVID-19-related research are comprehensively discussed as well.

Integrative Omics and Systems Pharmacology for COVID-19 provides state-of-the-art methods and applications of integrative omics and systems pharmacology for exploring treatments and medications for COVID-19, making it an ideal resource for researchers, lecturers, professors, experts, and students in diverse sub-fields and cross-fields of life sciences such as bioactive compounds, biochemistry, bioinformatics, biomedical science, computational biology, drug discovery, marine drugs, molecular docking, natural products, systems biology, systems/network pharmacology, general pharmacology, multiple omics, high-throughput technologies, traditional herbal medicines, viral diseases, and epidemiology.