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This technical report is designed to provide guidance to applicants for requests for a sealed source or device safety evaluations and registrations. It also provides the U.S. Nuclear Regulatory Commission (NRC) reviewers of such requests with the information and materials necessary to determine that the products are acceptable for licensing purposes. It provides the applicants and reviewers with information concerning how to file a request, a listing of the applicable regulations and industry standards, policies affecting evaluation and registration, administrative procedures to be followed, information on how to perform the evaluation and write a registration certificate, and the responsibilities of the registration certificate holder.