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Interventional operators generally expect complications when the coronary anatomy is tortuous; however, it is normal anatomy with what appear angiographically as 'regular' lesions that can cause great difficulty and additional morbidity. Drs Colombo's and Stankovic's team of first-rate, globally-recognized interventional cardiologists offer advice based on personal experience rather than didactic textbook knowledge on how to overcome a variety of complications both in the coronary anatomy as well as the carotid and renal arteries, two peripheral arteries with which they are operating with regularity.