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This substantially revised text represents a broader based biological engineering title. It includes medicine and other applications that are desired in curricula supported by the American Society of Agricultural and Biological Engineers, as well as many bioengineering departments in both U.S. and worldwide departments. This new edition will focus on a significant number of biological applications, problem-solving techniques, and solved examples. Specifically there will be 160+ interesting application problems over an entended biological base (biomedical, bioenvironmental, etc.) that were originally developed by the author throughout his 13 years of teaching this course at Cornell.