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Biotechnology of extremophiles - the applied science field that seeks to employ extremophilic organisms in order to discover in particular novel and unique useful biocompounds and genetic systems. This book aims to give a broad overview on the potential usage of extremophiles in biotechnology (e.g. industry, medicine, food, cosmetics, environmental clean-up, energy and fuel, geo-sciences), including the production of compounds (e.g. enzymes, compatible solutes) or the degradation of compounds such as xenobiotics etc. The book contains reviews on various recent discoveries, applications and visions of a large variety of extremophiles - focusing not only on prokaryotes, but also on eukaryotes as well as viruses.